Major 2025 overhaul: Euro 5+, on-the-move rear cylinder deactivation extended to standard V4 (since Rally 2023), auto-lowering, MotoGP DVO, 2nd-gen Skyhook EVO, radar Forward Collision Warning, new headlight. In 2026, the V4 RS receives the Panigale V4 Desmosedici Stradale engine.